Recent Publications
DeVore,N.M. and Scott, E.E. Cytochrome P450 17A1 structures with prostate cancer drugs abiraterone and TOK-001. Nature. DOI:
10.1038/nature10743.
DeVore, N.M., Meneely, K.M., Bart, A.G., Stephens, E.S., Battaile, K.P., and Scott, E.E.(in press)
Structural comparison of cytochromes P450 2A6, 2A13, and 2E1 with pilocarpine.
FEBS J.
Reed, T., Lushington, G.H., Xia, Y., Hirakawa, H., Mure, M., Scott, E.E., and Limburg, J. (2010)
Crystal structure of histamine dehydrogenase from Nocardioides simplex
J. Biol. Chem. 285:25782-25791.
Porubsky, P.R., Battaile, K.P., and Scott, E.E. (2010)
Human cytochrome P450 2E1 structures with fatty acid analogs reveal
a previously unobserved binding mode
J. Biol. Chem. 285:22282-22290.
Swanson, H.I., Njar, V.C.O., Yu, Z., Castro, D.J., Gonzalez, F.J., Williams,
D.E., Huang, Y., Kong, A-N.T., Doloff, J.C., Ma, J., Waxman, D.J., and
Scott, E.E. (2010) Targeting drug metabolizing enzymes for effective
chemoprevention and chemotherapy. Drug Metab. Dispos. 38:539-544.
Culpepper, M.A., Scott, E.E., and Limburg, J. (2010)
Crystal structure of prolyl 4-hydroxylase from Bacillus anthracis. Biochemistry 49:124-133.
DeVore, N.M., Smith, B.D., Wang, J.L., Lushington, G.H., and Scott, E.E. (2009)
Key residues controlling binding of diverse ligands to human cytochrome P450 2A Enzymes.
Drug Metab. Dispos. 37:1319-1327.
Porubsky, P.R., Meneely, K.M., and Scott, E.E. (2008)
Structures of human cytochrome P450 2E1: Insights into the binding of inhibitors and
both smallmolecular weight and fatty acid substrates.
J. Biol. Chem. 283:33698-33707.
DeVore, N.M., Smith, B.D., Urban, M.J., and Scott, E.E. (2008)
Key residues controlling phenacetin metabolism by human cytochrome P450 2A enzymes.
Drug Metab. Dispos. 36:2582-2590.
Miller, M.A., Scott, E.E., and Limberg, J. (2008)
Expression, purification, crystallization and preliminary X-ray studies of a
proly-4-hydroxylase protein from Bacillus anthracis.
Acta Crystallogr. F. 64:788-791.
Reed, T.M., Hirakawa, H., Mure, M., Scott, E.E., and Limberg, J. (2008)
Expression, purification and crystallization and preliminary X-ray studies of histamine dehydrogenase from Nocardiodes simplex.
Acta Crystallogr. F. 64:785-787.
Porubsky, P.R., Scott, E.E., and Williams, T.D. (2008)
p-Dimethylaminocinnamaldehyde derivatization for colorimetric detection and HPLC-UV/Vis-MS/MS identification of indoles.
Arch. Biochem. Biophys. 475:14-17.
Schlicht, K.E., Michno, N., Smith, B.D., Scott, E.E., and Murphy, S.E. (2007)
Functional characterization of CYP2A13 polymorphisms.
Xenobiotica. 37:1439-1349.
Smith B.D., Sanders J.L., Porubsky P.R., Lushington G.H., Stout C.D., and Scott, E.E. (2007)
Structure of the human lung cytochrome P450 2A13.
J. Biol. Chem. 282:17306-17313.
Scott E.E. and Halpert J.R. (2005)
Structures of cytochrome P450 3A4.
Trends in Biochem. Sci. 30:5-7.
Li W., Liu H., Scott E.E., Grater F., Halpert J.R., Luo X., Shen J., and Hiang H. (2005)
Possible pathway(s) of testosterone egress from the active site of cytochrome P450 2B1: A steered molecular dynamics simulation.
Drug Metab Dispos. 33:910-919.
Honma W., Li W., Liu H., Scott, E.E., and Halpert, J.R. (2005)
Functional role of residues in the helix B' region of cytochrome P450 2B1.
Arch. Biochem. Biophys. 435:157-165.