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Welcome to the De Guzman Lab
Our goal is to understand the molecular interactions involved in bacterial and viral pathogenesis. To achieve this, we determine the protein-protein, protein-RNA, and protein-drug interactions at high resolution using NMR and other biophysical methods. We also use mutagenesis and cell-based bioassays to correlate our structural results in vivo. Thus, students are expected to: (a) prepare their own samples by recombinant DNA techniques, (b) perform biophysical characterization of proteins such as CD and fluorescence spectroscopies and isothermal calorimetry, (c) determine the three dimensional structures of protein and protein complexes by NMR, and (d) perform mutagenesis and cell-based bioassays to correlate structural and biophysical data in vivo.
Discovering new knowledge ...