Peer-reviewed publications:

53. Lan L, Liu J, Xing M, Smith AR, Wang J, Wu X, Appelman C, Li K, Roy A, Gowthaman R, Karanicolas J, Somoza AD, Wang CCC, Miao Y, De Guzman RN, Oakley BR, Neufeld KL, Xu L.   Identification and Validation of an Aspergillus nidulans Secondary Metabolite Derivative as an Inhibitor of the Musashi-RNA interaction. Cancers, 12, 2221, 2020.

52. Dey S, Chakravarty A, Guha Biswas P, De Guzman RN.   The type III secretion system needle, tip, and translocon.   Protein Sci, 28, 1582, 2019. pdf

51. Lan L, Liu H, Smith AR, Appelman C, Yu J, Larsen S, Marquez RT, Wu X, Liu FY, Gao P, Gowthaman R, Karanicolas J, De Guzman RN, Rogers S, Aube J, Neufeld KL, Xu L.   Natural product derivative Gossypolone inhibits Musashi family of RNA-binding proteins.   BMC Cancer, 10, 809, 2018. pdf

50. Kato J, Dey S, Soto JE, Butan C, Wilkinson MC, De Guzman RN, Galan JE.   A protein secreted by the Salmonella type III secretion system controls needle filament assembly.   eLife, 7, e35886, 2018. pdf

49. Dey S, Anbanandam A, Mumford BE, De Guzman RN.   Characterization of Small Molecule Scaffolds that Bind to the Shigella Type III Secretion System Protein IpaD.   ChemMedChem, 12, 1534-1541, 2017. pdf

48. Kaur K, Park H, Pandey N, Azuma Y, De Guzman RN.   Identification of a New SUMO-Interacting Motif in PIASy.   J. Biol. Chem, 292, 10230-10238, 2017. pdf

47. Kaur K, Wu X, Fields JK, Johnson DK, Lan L, Pratt M, Somoza AD, Wang CCC, Karanicolas J, Oakley BR, Xu L, De Guzman RN.   The Fungal Natural Product Azaphilone-9 Binds to HuR and Inhibits HuR-RNA Interaction in Vitro. PLoS One, 12, e0175471, 2017. pdf

46. McShan A, Kaur K, Chatterjee S, Knight KM, De Guzman RN.   NMR Identification of the Binding Surfaces Involved in the Salmonella and Shigella Type III Secretion Tip-Translocon Protein-Protein Interactions. Proteins, 84, 1097-1107, 2016.

45. McShan AC, Anbanandam A, Patnaik S, De Guzman RN.   Characterization of the Binding of Hydroxyindole, Indoleacetic acid and Morpholinoaniline to the Salmonella Type III Secretion System Proteins SipD and SipB. ChemMedChem, 11, 963-971, 2016.

44. Kaur K, Chatterjee S, De Guzman RN.   Characterization of the Shigella and Salmonella Type III Secretion System Tip-Translocon Protein-Protein Interaction by Paramagnetic Relaxation Enhancement. ChemBioChem, 17, 745-752, 2016.

43. Chaudhury S, Nordhues BA, Kaur K, Zhang N, De Guzman RN.   NMR characterization of the type III secretion system tip chaperone protein PcrG of Pseudomonas aeruginosa. Biochemistry, 54, 6576-85, 2015.

42. Chaudhury S, de Azevedo SC, Plano GV, De Guzman RN.   The LcrG tip chaperone protein of the Yersinia pestis type III secretion system is partially folded. J. Mol. Biol. 427, 3096-3109, 2015.

41. Lan L, Appelman C, Smith AR, Yu J, Larsen S, Marquez R, Liu H, Wu X, Gao P, Roy A, Anbanandam A, Gowthaman R, Karanicolas J, De Guzman R, Rogers S, Aube J, Ji M, Cohen R, Neufeld K and Xu L.   Natural product (-)-gossypol inhibits colon cancer cell growth by targeting RNA-binding protein Musashi-1. Molecular Oncology 9, 1406-1420, 2015.

40. McShan AC, De Guzman RN.   The Bacterial Type III Secretion System as a Target for Developing New Antibiotics. Chem. Biol. & Drug Design. 85, 30-42, 2015.

39. Rathinavelan T, Lara-Tejero M, Lefebre M, Chatterjee S, McShan AC, Guo DC, Tang C, Galan JE, De Guzman RN.  NMR Model of PrgI-SipD Interaction and Its Implications in the Needle-Tip Assembly of the Salmonella Type III Secretion System. J. Mol. Biol. 426, 2958-69, 2014.

38. Chatterjee S, Chaudhury S, McShan AC, Kaur K, De Guzman RN.  Structure and Biophysics of Type III Secretion in Bacteria. Biochemistry. 52, 2508-17, 2013.

37. Chaudhury S, Battaile KP, Lovell S, Plano GP, De Guzman RN.  Structure of the Yersinia pestis tip protein LcrV refined to 1.65 A resolution. Acta Cryst. F. F69, 477-481, 2013.

36. Zhong D, Lefebre M, Kaur K, McDowell MA, Gdowski C, Jo S, Wang Y, Benedict SH, Lea SM, Galan JE, De Guzman RN.  The Salmonella Type III Secretion System Inner Rod Protein PrgJ is Partially Folded. J. Biol. Chem. 287, 25303-11, 2012.

35. Estrada DF, Conner M, St. Jeor SC, De Guzman RN.  The structure of the hantavirus zinc finger domain is conserved and represents the only natively folded region of the Gn cytoplasmic tail. Front. Microbio. 2, 251, 2011.

34. Estrada DF, De Guzman RN.  Structural characterization of the Crimean-Congo hemorrhagic fever virus Gn tail provides insight into virus assembly. J. Biol. Chem. 286, 21678-86, 2011.

33. Rathinavelan T, Tang C, De Guzman RN.  Characterization of the Interaction between the Salmonella Type III Secretion System Tip Protein SipD and the Needle Protein PrgI by Paramagnetic Relaxation Enhancement. J. Biol. Chem. 286, 4922-30, 2011.

32. Chatterjee S, Zhong D, Nordhues BA, Battaile, KP, Lovell, SW, De Guzman RN.  The Crystal Structures of the Salmonella Type III Secretion System Tip Protein SipD in Complex with Deoxycholate and Chenodeoxycholate. Prot. Sci., 20, 75-86, 2011.

31. Wang Y, Nordhues B, Zhong D, De Guzman RN.  NMR characterization of the interaction of the Salmonella type III secretion system protein SipD and bile salts. Biochemistry 18, 4220-6, 2010.

30. Rathinavelan T, Zhang L. Picking WL, Weis DD, De Guzman RN, Im W.  A Repulsive Electrostatic Mechanism for Protein Export through the Type III Secretion Apparatus. Biophys. J. 98, 452-461, 2010.

29. Estrada DF, Boudreaux DM, Zhong D, St. Jeor SC, De Guzman RN.  The Hantavirus Glycoprotein G1 Tail Contains a Dual CCHC-Type Classical Zinc Fingers. J. Biol. Chem. 284, 8654-60, 2009.

28. Wang Y, Boudreaux DM, Estrada DF, Egan CW, St. Jeor SC, De Guzman RN.  NMR structure of the N-terminal coiled coil domain of the Andes hantavirus nucleocapsid protein. J. Biol. Chem. 283, 28297-304, 2008.

27. Wang Y, Zhang L, Picking WL, Picking WD, De Guzman RN.  Structural dissection of the extracellular moieties of the type III secretion apparatus. Mol. BioSyst. 4, 1176-80, 2008.

26. Wang, Y, Ouellette, AN, Egan, CW, Rathinavelan, T, Im, W, and De Guzman, RN.  Differences in the electrostatic surfaces of the type III secretion needle proteins PrgI, BsaL, and MxiH. J. Mol. Biol. 371, 1304-1314, 2007.

25. Zhang, L, Wang, Y, Olive, AJ, Smith, ND, Picking, WD, De Guzman, RN, and Picking, WL.  Identification of the MxiH needle protein residues responsible for anchoring IpaD to the type III secretion needle tip. J. Biol. Chem. 282, 32144-32151, 2007.

24. Zhang, L, Wang, Yu, Picking, WL, Picking, WD, De Guzman, RN. Solution Structure of Monomeric BsaL, the Type III Secretion Needle Protein of Burkholderia pseudomallei. J. Mol. Biol. 359, 322-330, 2006.

8 Peer-reviewed publications at Scripps:

23. De Guzman RN, Goto NK, Dyson HJ, Wright PE.  Structural basis for cooperative transcription factor binding to the CBP coactivator. J Mol Biol. 355, 1005-1013, 2006.

22. De Guzman RN, Wojciak JM, Martinez-Yamout MA, Dyson HJ, Wright PE.  CBP/p300 TAZ1 domain forms a structured scaffold for ligand binding. Biochem 18, 490-497, 2005.

21. De Guzman RN, Martinez-Yamout MA, Dyson HJ, Wright PE. Interaction of the TAZ1 domain of the CREB-binding protein with the activation domain of CITED2: regulation by competition between intrinsically unstructured ligands for non-identical binding sites. J. Biol. Chem. 279, 3042-3049, 2004.

20. Kamikubo Y, De Guzman R, Kroon G, Curriden S, Neels JG, Churchill MJ, Dawson P, Oldziej S, Jagielska A, Scheraga HA, Loskutoff DJ, Dyson HJ.  Disulfide bonding arrangements in active forms of the somatomedin B domain of human vitronectin.  Biochemistry 43, 6519-6534, 2004.

19. Zor T, De Guzman RN, Dyson HJ, Wright PE.  Solution structure of the KIX domain of CBP bound to the transactivation domain of c-Myb.  J. Mol. Biol.. 337, 521-534, 2004.

18. Won HS, Low LY, De Guzman R, Martinez-Yamout MA, Jacob U, Dyson HJ.  The Zinc-dependent Redox Switch Domain of the Chaperone Hsp33 has a Novel Fold. J. Mol. Biol. 341, 893, 2004.

17. Dames SA, Martinez-Yamout M, De Guzman RN, Dyson HJ, Wright PE.  Structural basis for Hif-1 alpha /CBP recognition in the cellular hypoxic response.  Proc. Natl. Acad. Sci. U.S.A. 99, 5271-5276, 2002. 

16. De Guzman RN, Liu HY, Martinez-Yamout M, Dyson HJ, Wright PE. Solution Structure of the TAZ2 (CH3) Domain of the Transcriptional Adaptor Protein CBP.  J. Mol. Biol. 303, 243-253, 2000. 

7 Peer-reviewed publications at UMBC-HHMI:

15. Amarasinghe GK, De Guzman RN, Turner RB, Chancellor KJ, Wu ZR, Summers MF. NMR structure of the HIV-1 nucleocapsid protein bound to stem-loop SL2 of the psi-RNA packaging signal. Implications for genome recognition.  J. Mol. Biol. 301, 491-511, 2000.

14. Amarasinghe GK, De Guzman RN, Turner RB, Summers MF.  NMR structure of stem-loop SL2 of the HIV-1 psi RNA packaging signal reveals a novel A-U-A base-triple platform.  J. Mol. Biol. 299, 145-156, 2000.

13. Klein DJ, Johnson PE, Zollars ES, De Guzman RN, Summers MF.  The NMR structure of the nucleocapsid protein from the mouse mammary tumor virus reveals unusual folding of the C-terminal zinc knuckle.  Biochemistry 39, 1604-1612, 2000.

12. De Guzman RN, Wu ZR, Stalling CC, Pappalardo L, Borer PN, Summers MF.  Structure of the HIV-1 nucleocapsid protein bound to the SL3 psi-RNA recognition element. Science 279, 384-388, 1998.

11. Lee BM, De Guzman RN, Turner BG, Tjandra N, Summers MF.  Dynamical behavior of the HIV-1 nucleocapsid protein.  J Mol Biol. 279, 633-649, 1998.

10.McDonnell NB, De Guzman RN, Rice WG, Turpin JA, Summers MF.  Zinc ejection as a new rationale for the use of cystamine and related disulfide-containing antiviral agents in the treatment of AIDS.  J. Med. Chem. 40, 1969-1976, 1997.

9. Rice WG, Turpin JA, Huang M, Clanton D, Buckheit RW Jr, Covell DG, WallqvistA, McDonnell NB, De Guzman RN, Summers MF, Zalkow L, Bader JP, Haugwitz RD, Sausville EA.  Azodicarbonamide inhibits HIV-1 replication by targeting the nucleocapsid protein.  Nat. Med. 3, 341-345, 1997.

8 Peer-reviewed publications at UConn:

8.De Guzman, RN, Yan-Fei Shen, Brenda R. Shaw, Steven L. Suib, and Chi-Lin O'Young.  Role of Cyclic Voltammetry in Characterizing Solids: Natural and Synthetic Manganese Oxide Octahedral Molecular Sieves.   Chemistry of Materials 5, 1395-1400, 1993.

7. Y. F. Shen, De Guzman, RN, R. P. Zerger, S. L. Suib, C. L. O'Young.  Synthesis of Manganese Oxide Octahedral Molecular Sieves (OMS).  Studies in Surface Science and Catalysis 83, 19-24, 1994.

6. Y. G. Yin, W. Q. Xu, De Guzman, RN, Y. F. Shen, S. L. Suib, and C. L. O'Young.  Temperature Programmed Desorption and Reduction Studies of Octahedral Molecular Sieves.  Studies in Surface Science and Catalysis 84, 453-460, 1994.

5. Y. G. Yin, W. Q. Xu, De Guzman, RN, S. L. Suib, and C. L. O'Young.  Studies of Stability and Reactivity of Synthetic Cryptomelane-like Manganese Oxide Octahedral Molecular Sieves.  Inorganic Chemistry 33, 4384-4389, 1994.

4. De Guzman, RN, Yan-Fei Shen, Edward J. Neth, Steven L. Suib, Chi-Lin O'Young, Steven Levine, and John M. Newsam.  Synthesis and Characterization of Octahedral Molecular Sieves (OMS-2) Having the Hollandite Structure.  Chemistry of Materials 6, 815-821, 1994.

3. De Guzman, RN, A. Awaluddin, Y. F. Shen, Z. R. Tian, S. L. Suib, S. Ching, and C. L. O'Young.  Electrical Resistivity Measurements on Manganese Oxides with Layer and Tunnel Structures:  Birnessites, Todorokites, and Cryptomelanes.  Chemistry of Materials 7, 1286-1292, 1995.

2. Awaluddin, A. De Guzman, RN, Challa V. Kumar, Steven L. Suib,  Sandra L. Burkett, and Mark E. Davis.  Quenching of Tris(2,2'-bipyridine)ruthenium(II) Luminescence by Cobalt(III) Polypyridyl Complexes in Different Sites in and on Clays.  Journal of Physical Chemistry 99, 9886-9892, 1995.

1. Shen YF, Zerger RP, De Guzman RN, Suib SL, McCurdy L, Potter DI, O'Young CL.   Manganese Oxide Octahedral Molecular Sieves:  Preparation, Characterization, and Applications.  Science 260, 511-515, 1993.

Reviews, Invited Book Chapters & Patents

• De Guzman, RN. Bacterial Nanoinjectors. Chem. Biol. News & Res. 3, B87, 2008.

• De Guzman, RN; Martinez-Yamout, M; Dyson, HJ; & P.E. Wright.  Structure and Function of the CBP/p300 TAZ Domains, Chapter 17, Zinc Finger Proteins: From Atomic Contact to Cellular Function, Edited by Shiro Iuchi and Natalie Kuldell, Landes Bioscience, 2004.

• De Guzman RN, Turner RB, Summers MF. Protein-RNA recognition. Biopolymers 48, 181-195, 1998.  PMID: 10333745

• O’Young,CL;  Shen, YF; De Guzman, RN; &  Suib, SL.  Metal-substituted octahedral manganese oxide molecular sieves and their manufacture.  PCT Int. Appl. WO 95 25,693 (Cl. CO1B39/00), 28 Sep 1995, US Appl. 215,496, 21 Mar 1994.